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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison of Diagnostic Value of Rapid Diagnostic Test Standard Q towards Microscopic and Nested Polymerase Chain Reaction in Suspected Malaria Patients

Author: AMARENSI BETAUBUN, CHRISTOPHORUS OETAMA ADIATMAJA, TRIEVA V BUTARBUTAR, ARYATI, PUSPA WARDHANI
Abstract: Introduction: The diagnosis of malaria is still limited according to the gold standard microscopy, so Rapid Diagnostic Test (RDT) examination is needed. This study evaluated the RDT diagnostic value compared to microscopic examination and PCR as the gold standard. Methods: A cross-sectional observational study was conducted at the Regional Public Hospital of Merauke, Indonesia. Each specimen was examined by RDT using Standard Q Pf/Pv and Pan/Pf, and the gold standard by microscopic malaria using the Giemsa stain test and Nested PCR. Results: RDT Standard Q Pf/Pv compared to microscopy for detecting P. vivax was Sn:96.8%, Sp:97.6%, PPV:96.8%, and NPV:97.6% (Kappa:0.944), and for P. falciparum was Sn:88.9%, Sp:96.4%, PPV: 88.9%, and NPV: 96.4% (Kappa:0.853). RDT Standard Q Pf/Pan compared to microscopy for detecting P. falciparum was Sn:88.9%, Sp:96.4%, PPV: 88.9%, and NPV:96.4% (Kappa:0.853), and for non P. falciparum was Sn:90.5%, Sp:97.6%, PPV:96.6%, and NPV:93.1% (Kappa:0.887). Morever, RDT Standard Q Pf/Pv compared to Nested PCR for detecting P. vivax was Sn:92.5%, Sp:98.7%, PPV:98.4%, and NPV:94.0% (Kappa:0.917), and for P. falciparum was Sn:66.7%, Sp:97.9%, PPV: 94.4%, and NPV: 84.5% (Kappa:0.693). The sensitivity, specificity, PPV and NPV of the RDT Standard Q Pf/Pan compared to Nested PCR for detecting of P. falciparum infection were 66.7%, 97.9%, 94.4%, and 84.5%, respectively (Kappa:0.693). Whereas, the sensitivity and specificity for detecting non-P. falciparum infection were 86.6% and 98.7%, respectively, with PPV 98.3% and NPV 89.7% (Kappa:0.861). Conclusion: RDT showed good overall performance for detecting P. vivax but lower regarding sensitivity for detecting P. falciparum.
Keyword: Malaria, Microscopic, RDT, Nested PCR.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.206
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