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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Mechanism of Systemic Inflammatory Regulation in Sepsis Rat Models Through the Role of HMGB1, IL-1?, IL-10 and Procalcitonin in Statin Administration

Author: MUSOFA RUSLI, USMAN HADI, JUSAK NUGRAHA
Abstract: Background: Until now, the implementation of sepsis is done by eliminating the pathogen or toxin causing, and supportive therapy. There is no standard therapy that modulates the mechanism of an inflammatory response in sepsis. This study aimed to explain the regulatory mechanism of systemic inflammation in the rat models of sepsis after statin administration. Methods: This was an experimental study with true experimental research design with posttest time series control group design. The study was conducted at the Experimental Animal Laboratory of the Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia for three months (preparation until results). Results: The analysis showed no differences in body weight between groups before the treatment was given (p> 0.05). Procalcitonin (PCT) levels decreased significantly in the group with statins (X4 and X5) progressively at all hours of measurement. In contrast, PCT levels increased significantly at all hours of observation in the sepsis (X3) group. The greatest decrease in PCT occurred in the sepsis group who received statins and antibiotics (X5). The correlation test results between IL-1ß and IL-10 showed a moderate correlation at the 24th hour (r = 0.6; p = 0.0005) and the 36th hour (r = 0.6; p = 0.0002). Conclusion: Provision of statins can regulate pro-inflammation in animal models of sepsis and make effective anti-inflammatory activities in animal models of sepsis.
Keyword: Sepsis, HMGB1, Il-1ß, Il-10, Procalcitonin
DOI: https://doi.org/10.31838/ijpr/2020.12.04.202
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