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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Maternal Cardiovascular Risk in Five Years after Labor with Early- and Late-Onset of Severe Preeclampsia

Author: ADITIAWARMAN , ERNAWATI, HERMANTO TRI JOEWONO, MUHAMMAD ILHAM ALDIKA AKBAR, NOOR ASSYIFA ZULHIJAYAN
Abstract: Preeclampsia still becomes an important topic related to cardiovascular system health in more than 300 million women worldwide and has both short-term and long-term morbidity. This study aimed to learn maternal cardiovascular risk after 5 years after the diagnosis of early- and late-onset of severe preeclampsia. A retrospective cohort study involved all women meeting the inclusion criteria, who treated from January 2013 to January 2014, with early- and late-onset of severe preeclampsia diagnosis and get pregnancy termination in Dr. Soetomo General Hospital, Surabaya. The mean age of the subjects was in the range of 20-35 years, where age in the early-onset of severe preeclampsia group was older than the late-onset ones (32.12±6.827 years vs 28.2±7.890 years). There was a higher and significant cardiovascular risk factor related to hypertension and/or metabolic syndrome (p = 0.031) in the early-onset of severe preeclampsia group and supported an increase of 1.47 times cardiovascular risk factors (RR 1.471; CI 95 [1.071-2.019]) compared to the late-onset of severe preeclampsia group. The body mass index (BMI) and waist circumference of subjects were found higher in early-onset of severe preeclampsia (28.176±4.342 kg/m2 vs 25.892±3.956 kg/m2; 90.47±9.288 cm vs 83.48±9.283 cm). The maternal cardiovascular risks were hypertension and metabolic syndrome, which are more severe in the early onset of severe preeclampsia compared to the late-onset at 5 years after diagnosis.
Keyword: Preeclampsia, early-onset of severe preeclampsia, late-onset of severe preeclampsia, cardiovascular risk, hypertension, metabolic syndrome.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.196
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