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Prednisolone Loaded pH Sensitive Hydrogel Beads For Colonic Delivery
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| Author:
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UPLOADED BY-ADMIN, JITENDRA KUMAR RAI, UMESH KUMAR SHARMA, UMASHANKAR SHARMA, PAWAN KUMAR AGRAHARI, DHANANJAY RAI, ROHIT KUMAR, ABHISHEK SINGH
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| Abstract:
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The purpose of this research was to develop and evaluate multiparticulates delivery system of alginate and ethyl cellulose
hydrogel beads exploiting pH sensitive property for colon-targeted delivery of prednisolone. Alginate and ethyl cellulose
beads were prepared by extrusion method. pH sensitive alginate and ethyl cellulose hydrogel crosslinked with
glutaraldehyde was done for the controlled delivery of drugs to reduce its swelling properties for use as a vehicle in oral
delivery formulations, especially drug delivery systems aimed at localizing drugs in the distal portions of the small bowel.
Alginate is a non-toxic polysaccharide with favorable pH sensitive properties for intestinal delivery of prednisolone. Drug
leaching during hydrogel preparation and rapid dissolution of alginate at higher pH are major limitations, as it results in very
low entrapment efficiency and burst release of entrapped protein drug, once it enters the intestine. To overcome these
limitations, another natural polysaccharide, ethyl cellulose was included in the alginate matrix along with a cross linking
agent to ensure maximum encapsulation efficiency and controlled drug release. . All formulations were evaluated for particle
size, encapsulation efficiency, swellability and in vitro drug release in different pH. The crosslinked alginate–ethyl cellulose
hydrogel is novel and the drug loading process used in the study was mild and performed in aqueous environment. The
release profiles of a model drug prednisolone from test hydrogels were studied under simulated gastric and intestinal media.
Protein release from test hydrogels was minimal at pH 1.2 (??10%), and it was found to be significantly higher (??90%) at pH
7.4. Presence of guar gum and glutaraldehyde crosslinking increases entrapment efficiency and prevents the rapid dissolution
of alginate in higher pH of the intestine, ensuring a controlled release of the entrapped drug.
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| Keyword:
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colonic delivery, alginate, ethyl cellulose, prednisolone
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