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A study on the variability of drug responsiveness to anti inflammatory drugs - A pilot survey
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| Author:
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CASILDA SUSHANTHI.L, J. VIJAYASHREE PRIYADHARSINI, HANNAH.R, PRATIBHA RAMANI, GHEENA.S, ABILASHA RAMASUBRAMANIAM
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| Abstract:
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Responsiveness to a specific drug is driven by a complex interplay of factors which is known to influence both the pharmacodynamics and the pharmacokinetics of the drug. The pharmacokinetics defines the movement of drugs into and throughout the body by the process of absorption, distribution, metabolism and excretion, whilst pharmacodynamics is confined to the effects of the drug and the mechanism of action. The underlying factors which are known to precipitate variations in drug responsiveness are genetics, age and diseases. The present study aims to document the variations in drug responsiveness to anti-inflammatory drugs among a randomly selected group of individuals. Also the putative factors which could be related to the observation is also discussed.A pilot survey was conducted to identify the frequency of variations in drug responsiveness to anti-inflammatory drugs. The study was based on a standard questionnaire which included baseline details of the subjects such as age, gender along with information on pain, allergic reactions and drug responsiveness. The variables were then analysed using the Chi-square test using SPSS software version 20.0. The results were documented in the form of graphs.The frequency of male participants (65.4 %) was more when compared to the female participants (34.6 %). Among the 50 participants, 40 % of the male and 16 % of female had immediate pain relief after medication. 28 % of male and 16 % of females had pain relieved a few hours after medication. Subjects without any comorbid conditions were found to respond immediately to the drug when compared to other groups such as subjects suffering from diabetes mellitus, hypo/hypertension and hypo/hyperthyroidism. The variations in drug responsiveness among the study participants were found to be influenced by several factors including age, gender, comorbid conditions and habits. Although the present study did not yield significant results, the observation clearly presents the state of inter-individual variations with an underlying state which might be associated with genetic factors. Increasing the sample size and introducing data related to genetic variations in crucial genes would aid in deriving an association between drug responsiveness and the genetic markers.
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| Keyword:
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anti-inflammatory drugs, comorbid, dosage, drug response, habits
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0261
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| Download:
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