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Role of Natural Killer Cells in Innate Immunity - A Review
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| Author:
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S. BALAMITHRA, RAGHU NANDHAKUMAR, SMILINE GIRIJA AS
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| Abstract:
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Natura killer (NK) cells are a category of innate immune cells that have a cytolytic action against stressful cells, such as tumour cells and cells infected with viruses. It has two receptors, namely, activating receptor and inhibitory receptors. Activating receptors recognize the molecules that are expressed on the surface of cancer cells and virus infected cells, while inhibitory receptors are usually present in our body. Normal healthy cells known as Major Histocompatibility Complex (MHC) comprises two types, class I and class II. Major histocompatibility complex class I glycoprotein is found in all nucleated cells whereas in Major histocompatibility complex class II found only in special antigen presenting cells. Major histocompatibility complex class I acts as an inhibitory receptor. The role of MHC class I is to present intracellular protein to a cytotoxic T cell, while MHC class I is embodied in platelets. The articles reviewed are evaluated using Google scholar, pub med, Med Rxiv ,etc by analyzing about 30 articles. By reviewing all the articles, Natural killer cells act as an immunosuppressant and play a major role in immunity against the microbial and any viral pathogen infections.
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| Keyword:
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Natural killer cell, Cytokines, Bacterial infections, viral infection, tumor suppressor , immunosuppressant.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.253
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| Download:
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