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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Serum Lipid Profile after Treatment with Various Chemotherapeutic Scheduals in Iraqi Breast Cancer Patients

Author: ZAINAB ANBER
Abstract: Breast carcinoma is the most widespread neoplasm worldwide. It ranks first in causing death in Iraqi women. This study aimed to examine the influence of taxane, cyclophosphamide and doxorubicin on the lipid profile in Iraqi patients with breast cancer. This research was acheived in the Departement of Clinical Sciences , Baghdad College of Medical Sciences, and at the main Clinic of Oncology in Baghdad, Iraq, within the interval of June 2019 till November 2019. It included fifty six patients with the regular menstrual cycle (25-45 years) categorized into 3 groups: Group one GI: twenty nine patients with primary breast cancer (before begining chemotherapy), group two, GII: the same twenty nine patients of GI whose completed four circles of anthracyclines (course I) and group three, GIII: who included other twenty seven patients whose acheived both courses; (course one) and four circles of taxanes (course II). Serum total cholesterol (Tch), high- density lipoprotein (HDL), low- density lipoprotein (LDL) and triglycerides (TG) were analyzed using colorimetry based techniques. The outcomes of the current study appears that the (mean ± SEM) of the Tch was reduced significantly (p<0.05) within GIII in comparsion to GI and highly significantly (p<0.01) in comparsion to GII. While, the serum HDL level was significantly (p<0.05) decreased in GIII in comparsion to GI. Concerning the serum LDL level, it was raised significantly (p<0.05) in GII in comparsion to both GI and GIII. While; the serum TG level shows no significant difference between all groups. In conclusion, Iraqi women with breast cancer had an abnormal state of dyslipidemia that become worsened after chemotherapy.
Keyword: Chemotherapy, Breast cancer , cholesterol, LDL, HDL, TG.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.183
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