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Formulation and evaluation lipid polymer hybrid nanocarriers using a new innovative microwaves based method
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| Author:
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, , HAYDER KADHIM DRAIS, AHMED ABBAS HUSSEIN
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| Abstract:
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Numerous problems in drug manufacturing methods drive towards finding an alternative for continued growth in the pharmaceutical industry in a way that serves the patients and community health. Preparability was tested for the microwaves based method that depends on dipole rotation and ionic conduction. The experiment was very successful during the preparation attractive delivery system which is lipid polymer hybrid nanocarrier (LPHN). The prepared LPHNs (F1-F7) compose of hydroxypropylmethylcellulose( HPMC) E5 suspended in the lipid phase of garlic / oleic acid oils(1:1) and stabilized by Tween80/Tween 20 (4:1). The LPHNs(F1-F7) were subjected to thermodynamic stability evaluation, measurement of particle size, polydispersity index (PDI) and viscosity. The result was all formulations have nanosize diameter. The polydispersity index (PDI) was from (0.011 to 0.03). The zeta potential was (31.1 mV to 33.4 mV). The viscosity data of nanocarrier systems indicate non-Newtonian pseudoplastic rheological properties of prepared F1-F7. All the prepared nanoformulations have excellent features that make it promising drug delivery systems. From these nanocarriers (F1 –F7), the selected nanocarrier was F3 due to this nanocarrier contain more acceptable in drug loading efficiency and more controlled delivery.
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| Keyword:
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Lipid-polymer hybrid nanocarrier; microwave; HPMC.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.186
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| Download:
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