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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Ibuprofen Lozenges

Author: SIHAM ABDOUN, MALAK G. ALMUTAIRI
Abstract: Ibuprofen is a non-steroidal anti-inflammatory drug used to treat mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative, and dental pain and in the management of spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorders. It is available as tablet, capsule, chewable tablet, and oral suspension dosage forms. The lozenges dosage forms will increase bioavailability while reducing gastric irritation and bypasses first pass metabolism. Objective; The aim of the study was to design, formulate and evaluate Ibuprofen as lozenges dosage form to improve drug bioavailability and to reduce GIT side effects. Methods; Heating and congealing technique was used for the preparation of lozenges. Eudragit were used to mask bitter taste of ibuprofen. Results; The physicochemical parameter and in-vitro drug release of prepared formulations were evaluated. The average weight of lozenges was found (3.80 g ± 0.23), while their mean thickness and diameter were found (7.04 mm ± 0.29) and (20.30 mm ± 0.16) respectively; whereas the content was found 95.7± 0.36 for uncolored lozenges and 96.2 ± 0.31 for the colored one which within the acceptable limit of USP. Formulation showed maximum release of the drug within 30 minutes for the colored and uncolored lozenges (95.8% & 93.7%) respectively. The FTIR spectra revealed compatibility between the ibuprofen and eudragit. Conclusion; The moulded lozenges can provide an attractive alternative formulation with good bioavailability
Keyword: Ibuprofen, lozenges, formulation, in-vitro release.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.141
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