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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of antiamoebic activity of Ziziphus mauritiana leaf extracts in rats experimentally infected with Entamoeba histolytica

Author: MANSOUR ABDULNABI, H. MEHDI, MAZAHAR FAROOQUI, VIDYA PRADHAN
Abstract: The present study aimed to evaluate the activity of extracts of Ziziphus mauritiana leaves against Entamoeba histolytica in experimentally infected rats. In vivo anti-amoebic activity was assayed where twenty-one (Rattus norvegicus) rats were infected with E. histolytica and divided into seven groups. Groups (1,2 and 3) were treated with ethanolic Z. mauritiana extracts at doses 125, 250, and 500 mg/kg respectively for ten days. Groups (4,5 and 6) were treated with aqueous extract of Z. mauritiana at doses 125, 250, and 500 mg/kg respectively for ten days. Group (7) was left untreated as a positive control group. The results showed a significant decrease at p=0.05 in the numbers of parasite cells from the second day of treatment in all the groups treated with aqueous as well as ethanolic extract. This decrease gradually continued during the days of treatment until it reached zero on the 9th and 10th days of treatment for the dose of 500 mg/kg for both ethanol and aqueous extract respectively. Histopathological study showed that the ethanolic and aqueous extracts of Z. mauritiana at dose 500 mg/kg repairs the parasite damage in comparison with a range of positive and negative control groups. The results strongly support the traditional use of Z. mauritiana leaves for the treatment of diarrhea.
Keyword: Ziziphus mauritiana, Entamoeba histolytica, Rattus norvegicus, antiamoebic, Histopathology.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.076
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