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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effectiveness of biologically active substances from Hypericum Perforatum L. in the complex treatment of purulent wounds

Author: YURY VATNIKOV, PAVEL RUDENKO, MARINA SHOPINSKAYA, ANNA TOKAR, VERA ZHILKINA, DMITRY BOKOV, NATALIA BOBKOVA, NADEZHDA SACHIVKINA, EKATERINA LENCHENKO, ARFENIA KARAMYAN, EVGENY KULIKOV, SERGEY SHABUNIN
Abstract: The pharmacological activity of Hypericum (Hypericum Perforatum L.) in the complex treatment of purulent wounds in cattle is due to its pronounced antimicrobial properties, which are associated with the content of a number of biologically active substances, such as phenolcarboxylic acids and flavonoids, as well as phloroglucinols and naphthodiantrons. Created by us a phytosorbent of Hypericum by immobilizing an extract of the herb Hypericum (Hyperici perforati herbae extract) on silicon dioxide (SiO2), and also the study was conducted its effectiveness in the complex treatment of accidental purulent musculocutaneous wounds in cattle. It is shown that the use of Hypericum phytosorbent for medicinal purposes in case of accidental purulent wounds in cattle allows you to reduce the healing time of wounds by 1.1 times (p<0.01) faster than in the control group of animals. This is confirmed by the fact that in animals of the experimental group, complete wound cleansing occurred 1.8 days earlier (p<0.001) than in animals of the control group. It should be noted that granulations in the wounds of animals of the experimental group appeared 1.5 days earlier (p<0.01) than in the control group. Therefore, active epithelization of wounds in animals of the experimental group began 2.2 days earlier (p<0.001) than in the control group. The high therapeutic effect of the schemes that which used in animals of the experimental group is due to the usage of Hypericum holed phytosorbent in the first phase of the wound process, which contributed to the rapid cleaning of wounds and the transition of the wound process to the stage of regeneration, which ultimately led to rapid wound healing. Wound healing in animals of the experimental group ended with the formation of a mobile connective tissue scar, small in size, with a good cosmetic effect.
Keyword: Hypericum, silicon dioxide, phytosorbent, purulent wounds, cows.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.078
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0.12
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