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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Optimization of Bioactive extraction from Solanum Nigrum Leaves by Response Surface Methodology and its Encapsulation by Spray Drying for Functional Foods

Author: S. KAVIYA, S. KANDASAMY, K. KEERTHANA, R. MENAHA
Abstract: Solanum nigrum is recognized as a healthy plant due to its many health-promoting bioactive compounds. Phenolic and antioxidant properties are the main bioactive compounds in plant. Solanum nigrum leaves extract is recommended as an ingredient of many pharmaceutical products. However, the rather poor solubility of extract and their proneness to degradation during storage may decrease the extracts nutritional value. Encapsulation is a convenient way of improving solubility and extending the shelf-life of an extract. The spray drying is the most commonly and usually used technique among several encapsulation techniques. The main objective of this research is to study the optimization of microwave extraction of Solanum nigrum leaves and encapsulates the extract to reduce the bitterness and to hold the bioactive compounds. Optimization of the extraction from leaves using response surface methodology was carried out. The two variables, power of 661.69 watt and time of 4.38 mins were the optimized condition for the response variables of total phenolic content, total flavonoids content and antioxidant activity. Maltodextrin (MD), Gum Arabic (GA) and mixture of MD and GA are the three different wall materials used for encapsulating the extract. The ratio between leaves extract and wall material used is 1:20. The properties analyzed for encapsulated powder were moisture content, total phenolic content, encapsulation yield, encapsulation efficiency and microstructure of encapsulated particles. The result showed that the obtained optimized model could be used for extraction process and gum Arabic as the wall material were the suitable conditions for encapsulation, which produced the best encapsulation powder properties. The encapsulated powder may incorporated to food materials to get medicinal properties of Solanum nigrum.
Keyword: Solanum Nigrum Leaves, Extraction, Spray Drying, Encapsulation.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.152
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