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Folic Acid Supplementation Role on Bone Marrow and Blood Cells Morphology during Methotrexate Treatment
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| Author:
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SABAA ABID, MUSTAFA A. SAUD, ALAA A. ESMAEIL, MOHAMMED H. ASKER, TAHANI SALMAN AL-AZAWI
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| Abstract:
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This study was aimed to investigate the effect of folic acid on the hematological picture and bone marrow of rats treated and none treated with methotrexate. A total of 40 adult rats were divided in to 4 groups, C- control group, F- received 0.07mg/kg B.wt folic acid daily, M-were received 0.03mg/kg B.wt Methotrexate three times a week.FM- received folic acid daily and methotrexate three times a week. After the end of the experiment which lasted for 9 weeks, blood and bone marrow samples were taken. The results of MTX group reveal abnormal RBCs shape. The bone marrow smears reveal a case of megaloblastic anemia characterized by mild erythroid hyperplasia. The myeloid: erythoide ratio is 8:1. The group of animals that received FA with MTX showed a good prognosis which characterized by high significant improvement of studied parameters. The myeloid: erythroid ratio was 3:1. Therefore, it was concluded that FA administration with Methotrexate corrected the deleterious effects of MTX on erythrocyte parameters and bone marrow.
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| Keyword:
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Anemia, Folic Acid, Methotrexate, Bone Marrow.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.238
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| Download:
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