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Overview of phenomenological equations for powder compaction study
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| Author:
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UPLOADED BY-ADMIN, SANJAY S. PATEL, NATVARLAL M. PATEL
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| Abstract:
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In the new millennium, tablets will account for approximately 80% of all dosage forms administered
to humans. Tablets already hold a premier position among all dosage forms. Their easy of manufacturing,
high-precision dosing, patient compliance, and improved stability compared with oral liquids and
semisolids make tablets a popular and versatile dosage form. Compaction, an essential manufacturing step
in the manufacture of tablets, includes compression (i.e., volume reduction and particle rearrangement),
and consolidation (i.e., interparticulate bond formation). The success of the compaction process depends
not only on the physic-technical properties of drugs and excipients, especially their deformation behavior,
but also on the choice of instrument settings with respect to rate and magnitude of force transfer. This
overview highlights the mathematical equations used to describe compaction event. These equations describe
density–pressure relationships that predict the pressures required for achieving an optimum density.
Mathematical models, force-time, force-distance, and die-wall force parameters of tableting are used to
describe work of compaction, elasticity/plasticity, and time dependent deformation behavior of pharmaceuticals.
Various indices of tableting performance such as the bonding index, brittle fracture index, and
strain index can be used to predict compaction related problems.
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| Keyword:
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Compaction phenomena, Mathematical model, Heckel plot, Kawakita’s equation
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| DOI:
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