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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Overview of phenomenological equations for powder compaction study

Author: UPLOADED BY-ADMIN, SANJAY S. PATEL, NATVARLAL M. PATEL
Abstract: In the new millennium, tablets will account for approximately 80% of all dosage forms administered to humans. Tablets already hold a premier position among all dosage forms. Their easy of manufacturing, high-precision dosing, patient compliance, and improved stability compared with oral liquids and semisolids make tablets a popular and versatile dosage form. Compaction, an essential manufacturing step in the manufacture of tablets, includes compression (i.e., volume reduction and particle rearrangement), and consolidation (i.e., interparticulate bond formation). The success of the compaction process depends not only on the physic-technical properties of drugs and excipients, especially their deformation behavior, but also on the choice of instrument settings with respect to rate and magnitude of force transfer. This overview highlights the mathematical equations used to describe compaction event. These equations describe density–pressure relationships that predict the pressures required for achieving an optimum density. Mathematical models, force-time, force-distance, and die-wall force parameters of tableting are used to describe work of compaction, elasticity/plasticity, and time dependent deformation behavior of pharmaceuticals. Various indices of tableting performance such as the bonding index, brittle fracture index, and strain index can be used to predict compaction related problems.
Keyword: Compaction phenomena, Mathematical model, Heckel plot, Kawakita’s equation
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0.12
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