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Development and Characterization of a Superdisintegrant Enhanced Effervescent Tablet
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| Author:
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FASHLI RAZAK, CHIAU MING LONG, KAI BIN LIEW, NUR AISYAH MOHAMAD AZMAN
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| Abstract:
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Introduction
Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. It has become popular dosage form among patients who have difficulty in swallowing tablets and capsules.
Objective
The objective of this study was to formulate and evaluate effervescent tablet with the optimum percentages of effervescent agents and study the effect of addition of superdisintegrant.
Methodology
This study was divided into two parts. The effect of different percentages of citric acid and sodium bicarbonate on the effervescent tablet was studied in the first part of the study. The second part of the study was to formulate effervescent tablet with different percentages of sodium starch glycolate which acted as superdisintegrant. The effervescent tablets were evaluated based on their hardness, disintegration time, percentage of weight loss, uniformity in weight and thickness.
Result and discussion
Formulation 7 which contains 40% of effervescent agent and 10% of superdisintegrant has the fastest disintegration time (44.83 ± 6.97s) and sufficient crushing strength (4.32 ± 0.67kg). Conclusion: Formulation 7 was selected as optimum formulation in term of disintegration time due to a combination effect of effervescent and swelling of tablet.
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| Keyword:
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Superdisintegrant, Citric Acid, Sodium Bicarbonate, Sodium Starch Glycolate, Effervescent Tablet.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.276
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| Download:
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