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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Efficiency of Shrimp Extract (Astaxanthin) Histologically and Immunologically in the Treatment of Induced Diabetes Mellitus with Alloxan in Albino Male Rats

Abstract: The current study was conducted in the College of Education for Girls/ department of Biology/ animal house,50 male albino rats belonging to the Sprague Dawley strain were used. They weighed 180-228 g, and were divided into 7 groups, 5 males in each group. The first included control group that was orally dosed with a solution of physiological salt 0.9% NaCl. The second group was injected subcutaneously with alloxan 120 mg/kg. The third and fourth groups were orally administrated with astaxanthin extract at the two concentrations 250-500 mg/kg respectively. The fifth and sixth groups were injected with alloxan 120 mg/kg, and then was orally dosed with astaxanthin extract 250 and 500 mg/kg respectively. The last group was orally submitted to the amyral solution 0.1 mg/kg after being injected with alloxan 120 mg/kg. It is worth mentioning that the dosage process continued for 30 days, once per day. The study included recording of a rat's pancreas weight, blood glucose and monocyte chemotactic protein-1 (MCP-1) levels. In addition to the histological study that represented the sections of the pancreas. The results of the statistical analysis revealed a significant increase (P? 0.05) in the pancreas weight at the group that treated with alloxan, and the group was subjected to alloxan+amyral when compared with the control group and other experimental groups, while no significant differences (P? 0.05) when the other groups were compared with each other's. As well as, the findings recorded a significant elevation (P < 0.05) in levels of blood glucose and MCP-1 in the group injecting with alloxan subcutaneously and also the group of alloxan +amyral when compared with control group and the other groups, otherwise a significant decrease (P < 0.05) in the level of blood glucose and MCP-1 were noticed in the male rats that treated with astaxanthin 500 mg/kg when compared with all other groups of this study. The histological examination of pancreas of alloxan alone, and alloxan+ amyral treated animals diagnosed to obtain many of pathological changes comprised, degeneration and necrosis of some pancreatic islets, congestion and hemorrhage within the interstitial connective tissue, as well as expansion or widening of some blood vessels, severe infiltration of inflammatory cells within the pancreas tissues. The study concluded that the therapeutic effects of astaxanthin extract in the cocentration 500 mg/kg is better than the chemical drug (amyral) in improving the blood glucose level, due to the efficacy of the anti-oxidative constitutes found in astaxanthin which repairs the damages caused by alloxan 120 mg/kg in the histological structures and their cellular components of cytoplasm, nucleus and other organelles of the pancreas.
Keyword: Astaxanthin, Alloxan, Diabetes Mellitus, Pancreas.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.268
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