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Profile of pro-inflammatory interleukins in symptomatic epilepsy of various etiologies
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| Author:
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YAQUTHON MADJIDOVA, MAVJUDA MUKHITDINOVA, NODIRA KHAMIDOVA, VASILA ABDULLAEVA, GULCHEKHRA SADIIKOVA, ALIE KHALILOVA
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| Abstract:
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The objective of our study: To determine the profile of the spontaneous and mitogen-induced cytokine production in children with symptomatic epilepsy of different etiologies.
Materials and Methods: We examined 38 patients (aged between 3 and 18 years) with consequences of strikes (18.4%) neuroinfections (36.8%), neonatal brain injury (28.9%), and brain development anomalies (15.8%). The levels of spontaneous and mitogen-induced productions of the main cytokines (IL-2, IL-6, IL-1ß, TNF?) were determined by ELISA
Results: We traced the decrease and/or inhibition in the production of the main regulatory cytokines of monocyte-macrophage profile (TNFa, IL-1ß, IL-6) and adaptive immunity (IL-2) in children with symptomatic epilepsy; and we also revealed the insufficiency of the innate immunity factors in children, which was expressed in the suppression of the regulatory cytokine production, even with in vitro stimulation. The chronic course of the studied neurological conditions is a reflection of the condition of secondary immunodeficiency
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| Keyword:
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?hildren, symptomatic epilepsy, innate immunity, pro-inflamator cytokines.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.214
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| Download:
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