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Etodolac Topical Spray Films, Development, Characterization and In-Vitro Evaluation
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| Author:
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ZAINAB SADEQ, ZAHRAA SALIM, ESRAA GHAZY
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| Abstract:
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To develop a topical spray film of poorly water-soluble Etodolac (ET) using a combination of ?two different polymers; polyvinylpyrrolidone? (PVP) and ethyl cellulose (EC) plasticized ?with glycerin. Five films were prepared to contain 1% ET with different concentrations of ?ethyl cellulose (EC) with PVP and glycerin. The five formulations were characterized and evaluated for pH, content uniformity, spray angle, viscosity, the volume of solution delivered per each actuation, drying time and the in-vitro dissolution ?study.? The results indicate that as the concentration of EC decreases, the percentage of ET release will be increased, while the viscosity decreased. ?Spray angle of the prepared formulas may vary according to composition. Topical spray ?film containing 0.1% PVP and 0.02% EC regarded as the optimized formula, which shows the ?preferable pH and acceptable release. In conclusion the results indicate that the utility of fabricated of Etodolac topical spray film that offering sustained drug release to about 24 hours by using different concentrations of a polymer combined with a plasticizer.?
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| Keyword:
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Film-forming spray, Etodolac, topical, drug delivery
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.146
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| Download:
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Request For Article
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