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Preparation and evaluation of porosity osmotic pump tablets for sustain release of Glimepiride
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| Author:
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NUHA ABDULKHALEQ, AMAL A. ELKORDY, WEDAD K. ALI
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| Abstract:
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Porosity osmotic pump tablets (POPTs) were designed for delivering 8 mg Glimepiride in sustained release manner. These tablets were prepared by direct compression using 14 formulations containing different types of polymers (HPMC K100M, HPMC K4M, MMC PH 102, HPC-11, Eudragit L-100, Carbopol 934p and CMC Na) each alone or in combination. Sodium chloride was used as osmotic agent. The POPTs were coated with ethyl cellulose previously dissolved in ethanol with using castor oil as a plasticizer and coloring agent (Gingo red solution), the application of coating solution was performed by pan spray drier. Dissolution study showed that the type of polymer had a significant effect on the release of the drug from tablets; the highest retardation effect on the release of the drug was obtained with HPMCK100M and carbopol 934p. Whereas, using HPMCK 4M and CMC Na gave fastest release rates. Conversely, the use of HPMCK4M in combination with HPMCK100M or carbopol 934p in POPTs enhanced the release of the drug from these formulated tablets when compared with those obtained using each polymer alone. The effect of osmotic agent on the drug released showed that as the amount of NaCl was decreased the percentage of drug release from POPT formulations was decreased. Replacement MCC with Lactose monohydrate has no significant effect on percentage of drug released from POPTs, whereas Eudragit L100 showed different release profile. Amongst all formulations used in this study, F7 containing HPMC 100M was selected as the best formulation that provided sustained release Glimepiride over 24 hr.
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| Keyword:
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tablets; sustain release; POPTs; Drugs
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.126
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| Download:
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