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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Physicochemical Stability of Mixed Dexamethasone and Diclofenac Injection

Author: ZAINAB ABDUL, ZAID M ABDUL KHALIK, MOHAMMED KHUDHAIR HASAN, RAND FARHAD
Abstract: Aim This study was aimed to evaluate the in-vitro compatibility of mixing diclofenac sodium and dexamethasone sodium phosphate. Material Stability was assessed by HPLC methods were developed and validated according to international guidelines. The investigation performed by comparing the apparent peaks belongs to dexamethasone sodium phosphate and diclofenac sodium with peaks for a mixed solution. The investigation of the structure of dexamethasone and diclofenac by GC-MS (Shimadzu) was performed to determine the structural change after mixing. Results The rotation time of dexamethasone sodium phosphate were in 1.29, 2.18 and 3.28 minutes and for diclofenac, the rotation was at 3.99 minutes (Fig 1 and Fig 2). The rotation time of mixed solution was belonging to dexamethasone sodium phosphate plus diclofenac sodium as compared to a combination of figures (1) and (2). There was no additional peak that appeared for a mixed solution and that means no new compound was formed. Conclusion: The combination of dexamethasone and diclofenac is safe to use with no recognized drug-drug interaction.
Keyword: Dexamethasone sodium phosphate, Diclofenac sodium, HPLC, Stability, Drug-Drug interaction.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.123
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0.12
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