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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Serological detection and hematological changes associated with Toxoplasmosis in thalassemia patients in Al-Samawah province

Author: NUHA MOUSA
Abstract: Pateints of ß-thalassemia major who regularly receive blood transfusion are at risk of developing transplant-transmitted many diseases such as Toxoplasmosis :which is a common and a serious parasitic disease with a high prevalence and can be transmitted through blood transfusion from a healthy asymptomatic donors. However, screening Toxoplasma gondii before blood donation has not been measured. So The aim of this study was to determine the prevalence of T. gondii antibodies among thalassemia’s patients who are attended to Feminine and Children hospital in AL-Muthana.75 blood sample were collected from thalassemia patients and centrifuged to collect serum. Toxoplasma IGg &IgM Antibodies were examined by ELIZA assay. The positive sample were examined to study hematological change associated with infection. The seroprevalence of Toxoplasma infection among thalassemia pateints was 0.16% and 0.33% for IgM and IgG Anti-Toxoplasma antibodies, respectively. Whereas in the control group, the prevalence was 0.09% and 0.22% for IgM and IgG Anti-Toxoplasma antibodies, respectively. There is a significant statistical difference between thalassemia and control groups regarding the prevalence of toxoplasmosis. due to a high serologic infection rate of toxoplasmosis among thalassemia patients. Hematological parameters in whole blood samples were examined. Liver enzyme activity like aminotransferase (ALT), and Aspartate aminotransferase (AST) also urea and creatinine concentration in serum were determined. In infected groups ALT, AST activities, urea and creatinine concentration, were increased significantly p=0.05, while the Hb and PCV levels stay stable when compared to control groups.
Keyword: Toxoplasma, thalassemia, ELISA,
DOI: https://doi.org/10.31838/ijpr/2020.12.04.122
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