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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Physiological effects of Prozac on cellular and Humoral components of blood of laboratory mice

Author: SHAYMA HANOON, AIAD GABER AREAN, WISSAM SAJID HASHIM
Abstract: In this study, twenty four adult male albino mice were adopted and allocated randomly into three groups of eight mice each to elucidate the effects of fluoxetine. The experiment extended for three months. The animals of control group were dosed orally with distilled water. The animals of fluoxetine treated group (Fluox L) were dosed orally with fluoxetine 2mg/mouse. The animals of fluoxetine treated group (Fluox H) were dozed orally with fluoxetine 4mg/mouse. The results revealed that the treatment with fluoxetine caused significant declination in R.B.C., HB, HCT, neutrophils (neutropenia) MCH, MCHC, MCV and MPV with significant elevations in total white blood cells count (Leukocytosis), eosinophilia, monocytosis and platelets (Thrombocytosis). All these effects of fluoxetine were positively proportioned with the increase in dose of fluoxetine as we comparing with normal group P-value less than 0.05.
Keyword: MCHC, MCV, MPV
DOI: https://doi.org/10.31838/ijpr/2020.12.04.115
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0.12
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