*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Comparative efficacy of ethanolic and aqueous extracts of Curcuma zedoaria Rosc root on behavioral and radiology changes in arthritic rats

Author: UPLOADED BY-ADMIN, MADAN L. KAUSHIK, SUNIL S. JALALPURE
Abstract: Preclinical evaluation is an essential step in the assessment of new anti-inflammatory and antiarthritic drugs. This study was to investigate the effect of ethanolic and aqueous extracts of Curcuma zedoaria Rosc (Zingiberaceae), Root on behavioural and radiological changes in arthritic rats. Freund,s Complete Adjuvant-induced arthritis was followed over 42 days of postinoculation period in left ankle joint of Wistar albino rats using an open field test. Behavioural observations were made on 0, 3, 7, 14, 21, 28, 35, and 42 days and radiography study was performed at 42 day after drug treatments. Behavioural observations included latency time, ambulatory, rearing, grooming, urination and defecation. Radiography parameters included, soft tissue swelling, erosions of bone extremities, and joint space narrowing. Rats were divided into eight groups (n = 6), selected doses were indomethacin 10 mg/kg.i.p, 200 mg/kg,p.o, marketed herbal drug Rumalaya forte and 200, 400 mg/kg.p.o of ethanol and aqueous extracts respectively. Quantified behavioural changes in arthritis rats were decreased ambulation and rearing, whereas increased latency time, grooming, urination and defecation were observed in the control group. The standard drugs and extract treated groups showed significant (p<0.001) recovery in behavioural changes except aqueous groups compared with 0 day. On the basis of radiography examination control and aqueous groups showed highest swelling in left ankle joint of rats as compared to normal group joint. Groups treated with standards and extracts showed significant reduction in swelling on 42 day. However both doses of ethanolic extract of Curcuma zedoaria showed highly effective and appreciable results by impairing intension for improvement in arthritis.
Keyword: Anti-arthritic, Curcuma zedoaria, open field test, behavioral study, radiography
Download: Request For Article
 
Clients

Clients

Clients

Clients

Clients
ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free