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Comparative efficacy of ethanolic and aqueous extracts of Curcuma zedoaria Rosc root on behavioral and radiology changes in arthritic rats
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UPLOADED BY-ADMIN, MADAN L. KAUSHIK, SUNIL S. JALALPURE
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| Abstract:
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Preclinical evaluation is an essential step in the assessment of new anti-inflammatory and antiarthritic drugs. This study was
to investigate the effect of ethanolic and aqueous extracts of Curcuma zedoaria Rosc (Zingiberaceae), Root on behavioural
and radiological changes in arthritic rats. Freund,s Complete Adjuvant-induced arthritis was followed over 42 days of
postinoculation period in left ankle joint of Wistar albino rats using an open field test. Behavioural observations were made
on 0, 3, 7, 14, 21, 28, 35, and 42 days and radiography study was performed at 42 day after drug treatments. Behavioural
observations included latency time, ambulatory, rearing, grooming, urination and defecation. Radiography parameters
included, soft tissue swelling, erosions of bone extremities, and joint space narrowing. Rats were divided into eight groups (n
= 6), selected doses were indomethacin 10 mg/kg.i.p, 200 mg/kg,p.o, marketed herbal drug Rumalaya forte and 200, 400
mg/kg.p.o of ethanol and aqueous extracts respectively. Quantified behavioural changes in arthritis rats were decreased
ambulation and rearing, whereas increased latency time, grooming, urination and defecation were observed in the control
group. The standard drugs and extract treated groups showed significant (p<0.001) recovery in behavioural changes except
aqueous groups compared with 0 day. On the basis of radiography examination control and aqueous groups showed highest
swelling in left ankle joint of rats as compared to normal group joint. Groups treated with standards and extracts showed
significant reduction in swelling on 42 day. However both doses of ethanolic extract of Curcuma zedoaria showed highly
effective and appreciable results by impairing intension for improvement in arthritis.
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| Keyword:
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Anti-arthritic, Curcuma zedoaria, open field test, behavioral study, radiography
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| DOI:
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