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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Purple Sweet Potato Extract Administration to Cigarette Smoke Exposure towards The Number of Androgen Receptors: Randomized controlled trial

Author: , I GUSTI AYU RATIH AGUSTINI*, I NYOMAN MANGKU KARMAYA, I MADE JAWI, BAGUS KOMANG SATRIASA
Abstract: Negative effects of free radicals will occur when the amount exceeds the ability of the antioxidant defense system in the body that can cause oxidative stress conditions in the testicles. The anticipation of oxidative stress can be done by administering antioxidants. Epidemiological studies show that antioxidants are abundant in some plants and fruits. Antioxidant compounds found in purple sweet potato are anthocyanin, flavonoids, phenolics, alkaloids, saponins, and tannins. Anthocyanin has a high ability as an antioxidant because of its ability to capture free radicals and inhibit fat peroxidation. This study uses The Randomized Post-test only with control group design. The number of research samples was 30 mice. The measurement of androgen receptor expression is done by immunohistochemistry using the Bioss AR kit. Data analysis was performed with the One-Way ANOVA (Analysis of Variance) and the post hoc test using the Bonferroni test. The highest average androgen receptor is in the T2 group with a value of 41.5620 wherein this group, a purple sweet potato extract, was given at a dose of 400 mg/Kg after the exposure to cigarette smoke. Meanwhile, the lowest value in the control group is 14.7570, where this group is only given normal liquid saline after exposure to cigarette smoke. All groups have significant differences with p = 0.0001 <0.05. However, when viewed from the mean difference, the T2 group, namely the group given purple sweet potato extract with 400mg/KgBW doses, had the highest mean difference compared to the control group and the T1 group. The mechanism of purple sweet potato extract in increasing androgen receptors in mice that are given exposure to cigarette smoke is through the role of active secondary metabolites that is active in purple sweet potato tubers, namely anthocyanin.
Keyword: purple sweet potato extract, cigarette smoke exposure, androgen receptors.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.140
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