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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Association between Serum Leptin Level and Insulin Resistance in Acromegalic Iraqi Patients with Type 2 Diabetes Mellitus

Author: HIND AHMED, WALAA AHMED AL-JEDDA, NOOR THAIR TAHIR
Abstract: Acromegaly is an infrequent, chronic disease, manifested by hypersecretion of growth hormone, alongside with higher levels of insulin like growth factor-1. Both hormones play as mediators affecting glucose homeostasis. This study aims to investigate the association between serum leptin level and insulin resistance in acromegalic Iraqi patients with type 2 diabetes mellitus. This study was conducted on group of 45 acromegalic patients attending The National Diabetic Center/ Al-Mustansiriyah University-Baghdad during the period of December 2018 to August 2019. All acromegalic patient with known history of diabetes and their ages ranged between 30-60 years, who gave the consent for the study and diagnosed by physician were included in the current study. They were compared with 45 healthy subjects as control group. The present data revealed a significant increase (p = 0.05) in glycemic tests in acromegalic patients as compared to the controls. There was a significant increase (p= 0.03) in homeostasis model assessment for insulin resistance-2 in acromegalic patients as compared to the controls (8.94±4.22 vs. 4.29±2.62), also a significant increase (p= 0.01) in serum leptin level was found in patients group as parallel to the controls (22.13±4.62 vs. 12.36±2.31) ng/ml for. Additionally, there was a significant positive correlation (p = 0.05) between insulin resistance and glycemic tests, growth hormone, insulin like growth factor-1, and leptin levels in acromegalic patients with type 2 diabetes mellitus. The current results show that acromegalic patients had deranged metabolism and higher serum levels of insulin, , insulin like growth factor -1, and leptin.
Keyword: Acromegaly, Diabetes mellitus, Insulin resistance, Growth hormone, Insulin like growth factor-1, Leptin.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.136
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