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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and Evaluation of IER based Formulation of Ondansetron HCl

Author: NADIR KHAN, HARJEET SINGH, VIDHAN CHAND BALA, VIKAS ANAND SAHARAN
Abstract: Context: Ion exchange resin is a viable approach to improve the unpleasant taste of better drug, especially for patient compliance. Ondansetron HCl is a bitter antiemetic drug, used as the treatment of vomiting and nausea. The emetic patient requires quicker onset of action, there is a need to develop FDTs. FDTs overcome problems such as difficulty in swallowing. Materials and methods: In this study, taste masked complexes were prepared in various ratio such as (1:1, 1:2, 1:3 and 1:4) of Amberlite IRP69. Prepared complexes were characterized by FTIR spectroscopy, particle size, dissolution and in vitro taste evaluation. Taste masked FDTs were prepared by direct compression. Then, all tablet formulations were evaluated for hardness, disintegration time, wetting time, friability, thickness and dissolution. Results: The complexes with varying ratio of Amberlite IRP69 to Ondansetron HCl had taste masking ability. The best result of the complex was achieved for drug: IER ratio of 1:3. Taste masked Ondansetron HCl; FDTs were prepared which had good hardness 2.9- 3.3 kg/cm2. And disintegration time of 58- 43 sec. FDTs showed 87% drug release in 30 min which is required for quicker onset of action. Conclusion: IER complexes provide sufficient taste masking without reducing the release of the drug from the complexes. FDTs of ondansetron HCl were prepared by direct compression method for immediate drug release and fast disintegration.
Keyword: Taste masking, Ion exchange resin, Fast dissolving tablets, Ondansetron hydrochloride, Amberlite IRP69, Sodium Starch Glycolate.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.111
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