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Expression of tissue-specific genes in mice with hepatocarcinogenesis
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| Author:
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NIZOM ERMATOV, GULMIRA KASSYMOVA, GULMIRA KASSYMOVA, KHOSIYAT TAJIYEVA, MUKHARRAMA KHASANOVA, MAVJUDA ALIMUKHAMEDOVA, SEVARA AZIMOVA
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| Abstract:
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Hepatocarcinogenesis is a multi-stage process associated with a change in the spectrum of the genes expressed
by the cell. The scheme of molecular mechanisms leading to malignancy of hepatocyte is still not fully
characterized. Objective: To study the general patterns of gene expression dysfunction during the progression
of hepatocellular carcinomas. To this end, we studied the results of studies of 28 mice that were induced by a
single injection of diethylnitrosamine. As a result of the data obtained, the relationship between specific
transcriptional regulators and the level of tumor differentiation is shown. Based on the study, it can be
assumed that analysis of changes in the expression levels of tissue-specific genes in clinical samples will allow us
to answer the question of the validity of the revealed patterns for human hepatocarcinogenesis.
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| Keyword:
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hepatocarcinoma, tissue-specific genes, expression, types of hepatocarcinomas, histological structure.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.245
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| Download:
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