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The influence of gestational age and neurological status of premature infants on hemostasis
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| Author:
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YAKUTKHON MADJIDOVA, ZIYODA AKHMEDOVA, AZIZA DJURABEKOVA, NARGIZA ABDULLAEVA, ZULFIYA YAKUBOVA
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| Abstract:
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Hemostasis disorders in preterm infants occur more often than in full-term ones due to the immaturity of the
coagulation system, and lead to the appearance of hemorrhagic syndrome [1, 2]. Various forms of blood
coagulation disorders in newborns can be both primary, with independent nosological significance, and
secondary, if they are an intermediate link in the pathogenesis of many serious diseases and processes,
significantly affecting the course and outcomes, making the main pathogenetic therapy ineffective [3].
Monitoring of hemostasis indices is necessary both timely assessment and preclinical diagnosis of hemorrhagic
and thrombotic manifestations, and for evaluating the effectiveness of treatment. To assess such deviations, it
is necessary to know the normative indicators of hemostasis, which are determined for full-term, but to a
lesser extent - for premature infants. Of particular importance for the correct assessment of hemostatic
disorders is the knowledge of the characteristics of changes in hemostasiological parameters in the dynamics of
the early neonatal period. Currently, they defined for full-term [4, 5] and to a lesser extent for premature
newborns [6].
Currently, there are no comprehensive data on hemostasis in preterm infants performed on modern analytical
systems, and therefore the goal of this work was to refine the characteristics of plasma hemostasis in preterm
infants taking into account their gestational age (GA).
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| Keyword:
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newborns, premature infants, hemostatic system, coagulation system, cerebral circulation
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.237
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| Download:
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