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Myocardial remodeling after myocardial infarction in distant period.
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| Author:
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OLGA OSIPOVA, NATALIA V. GRIGORENKO, VLADISLAV V. BUKATOV, ?KSANA N. BELOUSOVA, TATYANA A. PETRICHKO
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| Abstract:
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The flip side of reducing mortality from acute myocardial infarction is the progressive growth of patients with post-infarction cardiosclerosis and the development of heart failure. Unfortunately, numerous scientific researches aimed at studying the post-infarction heart failure do not provide reliable answers to methods for the prevention of pathological remodeling and thus many problems remain unstudied today. The analysis of the studied literature data describing the features of myocardial remodeling after acute myocardial infarction. We analyzed modern domestic and foreign literature including PubMed, E-library, Web of Science, Scopus data presented in modern scientific databases on epidemiology, neurohumoral features, morphological picture of myocardial remodeling in the early and distant periods after myocardial infarction. Based on the analysis of modern literature that describes the mechanisms and features of the development of heart failure after a heart attack, we revealed that the spread of post-myocardial infarction heart failure has been steadily increasing in recent years. Myocardial remodeling can last from several days to several years until the tissues of the emerging collagen scar are balanced. Neurohumoral factors affect 3 main components of the myocardium: cardiomyocytes, extracellular matrix and capillary microcirculation. Dysfunction of any of these components can lead to pathological myocardial remodeling. Many neurohumoral factors such as the renin-angiotensin-aldosterone system (RAAS) were studied reliably in the process of remodeling and some factors like matrix metalloproteinases (MMPs) remain understood poorly although it is known reliably that they play an important role in the processes of myocardial scarring. Reparative processes are regulated by cytokines, prostaglandins and other humoral factors and remain understood poorly.
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| Keyword:
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Coronary heart disease (CHT) ST segment elevated myocardial infarction (STEMI), postinfarction cardiosclerosis, cardiac remodeling, chronic heart failure, renin-angiotensin-aldosterone system, matrix metalloproteinases.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.208
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| Download:
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