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Correlation Analysis of Vascular Remodeling Indicators, Adaptive Homeostasis Parameters, Microcirculation, Cardiovascular System Functional Parameters in Patients with Arterial Hypertension and Symptoms of Accelerated Aging
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| Author:
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SVETLANA GORELIK, , ANDREI N. ILNITSKY, SVETLANA V. BULGAKOVA, EKATERINA V. TRENEVA, NATALYA O. ZAKHAROVA, HOVHANNES V. DAVIDYAN
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| Abstract:
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In recent years, methods for evaluating the elastic properties of the arterial wall, the integral parameter characterizing the process of vascular remodeling, the predictor of cardiovascular diseases and complications are becoming more and more relevant.
Materials and methods: The study is based on the results of clinical and instrumental examination of 63 male middle-aged patients with arterial hypertension of stage II and degree1, high risk with signs of accelerated aging. The clinical, laboratory and instrumental examinations have been performed.
Results: The conducted research and the correlation analysis implemented on its basis have shown that the key indicators that are highly correlated with vascular stiffness include evening secretion and circadian rhythm of cortisol secretion, high-density lipoproteins, atherogenicity coefficient, adrenaline-induced platelet aggregation, microcirculation efficiency index, capillary blood flow reserve, blood flow semi-recovery time, indicators of myocardial diastolic dysfunction, total peripheral vascular resistance, heart rate, blood pressure variability, the magnitude and rate of morning blood pressure rise.
Conclusion: Determination of the above parameters even in the absence of instrumental diagnosis of vascular stiffness will allow for timely detection and correction of pathological changes, slowing the progression of cardiovascular disease and preventing the development of vascular accidents.
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| Keyword:
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arterial hypertension, accelerated aging, vascular remodeling, homeostasis
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.206
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| Download:
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