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A preclinical study on targeting glucose homeostasis using therapeutic intervention of ZnO nanoparticles
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| Author:
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DR. RAUT, DR. BISWADEEP DAS, DR. TANIA PAUL, DR.GAURI KULKARNI
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| Abstract:
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Myriads of research work is undertaken on Zinc oxide Nanoparticles (ZnO) but avenues for finding alternate therapy in Hyperglycemic is always open. Present study was put forth to determine the antihyperglycemic activity of 50 nm ZnO on Streptozotocin (STZ) induced Diabetic rats. To determine the interplay of oral hyperglycemic agents in controlling hyperglycemic activity when co administered with ZnO was the primary aim of the study. It was successfully achieved when ZnO and Glipizide was administered singly and in combination for 28 Days orally to diabetic rats. Streptozotocin induced diabetes causes oxidative stress in rats which is also evident in humans due to impairment of insulin release and concomitant rise in glucose. Therefore, attempts are made to reduce these free radical damage by use of ZnO. The microartchitecture of pancreas, liver and kidney which was disturbed in Diabetic rats were restored to near normal by the present intervention of ZnO singly and in combination with Glipizide- a sulphonylurea derivative. Hence, it can be concluded that ZnO can be used in future for managing metabolic disorders like Diabetes and Obesity as a therapy or as a carrier to accommodate oral hyperglycemic agent for easy drug delivery and bioavailability.
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| Keyword:
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Zinc Oxide Nanoparticles, Streptozotocin, Glipizide, Antioxidant, Histopathology
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.200
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| Download:
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