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Formulation and Evaluation of Solid Lipid Nanoparticles of Prednisolone
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| Author:
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UPLOADED BY-ADMIN, C.VIJAYA, D.KALYANA NARASIMHA
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| Abstract:
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Prednisolone, a glucocorticoid, is used for a variety of inflammatory diseases. Controlled delivery of prednisolone from
nanoparticles may alleviate the serious side effects associated with its long term use. The present work was carried out to
prepare solid lipid nanoparticles of prednisolone and to evaluate them for controlled release. Prednisolone loaded solid lipid
nanoparticles were prepared with stearic acid, soya lecithin and sodium taurocholate by warm o/w microemulsion method at
different levels of lipid matrix and drug and evaluated for physicochemical parameters such as size, surface morphology,
zeta potential and extent of encapsulation. The in vitro drug release pattern was examined by studying diffusion of drug
through dialysis membrane using phosphate buffer saline as drug release medium. The size range of the prepared solid lipid
nanoparticles was between 175 to 500 nm as observed by scanning electron microscopic analysis. Zeta potential
measurement confirms the stable colloidal nature of solid lipid nanopartcles dispersion. Encapsulation of prednisolone in
nanoparticles was in the range of 75 – 90 %. The release of prednisolone from the formulations was found to be extended
over 24 hours (28.4%- 56.4%). Reduced drug release with increased drug content of nanoparticles indicates the enhanced
solubility of lipophilic prednisolone in lipid matrix. Another exceptional observation was greater drug release with an
increase in lipid content of the solid lipid nanoparticles. Linear Higuchi plots obtained in the drug release kinetics analysis
prove the mechanism of drug release to be the matrix diffusion.
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| Keyword:
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Warm microemulsion, prednisolone, solid lipid nanoparticles, zeta potential
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| DOI:
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