IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Fertility recovery from polycystic ovarian syndrome

Author: BAHODIR IBRAGIMOV, DILDORA KHUDOYAROVA, NADIYA IBRAGIMOVA, ZARINA KOBILOVA
Abstract: Polycystic Ovarian Syndrome (PCOS) is a multifactorial heterogeneous pathology characterized by menstrual disorders, chronic anovulation, hyperandrogenia, cystic changes in the ovaries and infertility. The frequency of this pathology is about 11% in women of fertile age, and in the structure of endocrine infertility reaches 70%. The aim of this study is to develop modern methods of infertility treatment in women with polycystic ovarian syndrome based on the study of clinical and anamnestic and laboratory indicators, some genotypic variants of genes polymorphisms, folate metabolism. A total of 150 patients with suspected PCOS with ovarian infertility were examined. We analyzed the efficacy of the algorithm of examination and treatment of infertile patients with homocysteine levels, and also studied the role of different genotypic variants of polymorphic genes MTHFR (C677T, A1298C), MTR (A2756G), MTRR (A66G) folate metabolism in the formation of PCOS. The expediency of additional use of ovulation inductors on the background of folate intake and endosurgical methods in patients with this syndrome has been clarified. The efficacy of the ovulation induction algorithm by successive use of Clomiphenzitrate and a combination of CC+PFSH in clomiphen-resistant patients at the stages before and after the use of endosurgical treatment methods in the background of folate administration was assessed. The results of the conducted studies showed that the cause of chronic anovulation and, as a result, infertility in patients with PCOS may be hormonal abnormalities detected in 82% of patients. The most typical for HPCJ was an increase in total testosterone - in 63.3% of patients, an increase in the LH/FSH ratio of more than 2.5 was observed in 51.3% of patients. Rational infertility treatment can restore fertility in 40% of cases.
Keyword: Polycystic Ovary Syndrome (POS), normalization of body weight, correction of metabolic disorders, stimulation of ovulation, antagonists of gonadotropin releasing factor, combined oral contraceptives (COCs), in vitro fertilization (IVF).
DOI: https://doi.org/10.31838/ijpr/2020.12.04.096
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free