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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Fertility recovery from polycystic ovarian syndrome

Author: BAHODIR IBRAGIMOV, DILDORA KHUDOYAROVA, NADIYA IBRAGIMOVA, ZARINA KOBILOVA
Abstract: Polycystic Ovarian Syndrome (PCOS) is a multifactorial heterogeneous pathology characterized by menstrual disorders, chronic anovulation, hyperandrogenia, cystic changes in the ovaries and infertility. The frequency of this pathology is about 11% in women of fertile age, and in the structure of endocrine infertility reaches 70%. The aim of this study is to develop modern methods of infertility treatment in women with polycystic ovarian syndrome based on the study of clinical and anamnestic and laboratory indicators, some genotypic variants of genes polymorphisms, folate metabolism. A total of 150 patients with suspected PCOS with ovarian infertility were examined. We analyzed the efficacy of the algorithm of examination and treatment of infertile patients with homocysteine levels, and also studied the role of different genotypic variants of polymorphic genes MTHFR (C677T, A1298C), MTR (A2756G), MTRR (A66G) folate metabolism in the formation of PCOS. The expediency of additional use of ovulation inductors on the background of folate intake and endosurgical methods in patients with this syndrome has been clarified. The efficacy of the ovulation induction algorithm by successive use of Clomiphenzitrate and a combination of CC+PFSH in clomiphen-resistant patients at the stages before and after the use of endosurgical treatment methods in the background of folate administration was assessed. The results of the conducted studies showed that the cause of chronic anovulation and, as a result, infertility in patients with PCOS may be hormonal abnormalities detected in 82% of patients. The most typical for HPCJ was an increase in total testosterone - in 63.3% of patients, an increase in the LH/FSH ratio of more than 2.5 was observed in 51.3% of patients. Rational infertility treatment can restore fertility in 40% of cases.
Keyword: Polycystic Ovary Syndrome (POS), normalization of body weight, correction of metabolic disorders, stimulation of ovulation, antagonists of gonadotropin releasing factor, combined oral contraceptives (COCs), in vitro fertilization (IVF).
DOI: https://doi.org/10.31838/ijpr/2020.12.04.096
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