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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Monooxygenase liver system in functional changes of the thyroid gland in experiment

Author: NASIRDJAN YULDASHEV, MOHIDIL RASULOVA, MAHAMADJAN NISHANTAEV, MUHAMMADAMIN SHERTAEV, GULCHEHRA SULEYMANOVA
Abstract: The aim of the study was to assess the state of the monooxygenase system of the liver in experimental hypo- and hyperthyroidism in rats. Hypothyroidism in rats was caused by intraperitoneal injection of mercazolil at a dose of 1 mg per 100 g of body weight for 15 days, and hyperthyroidism was caused by injection of L-thyroxine at a dose of 400 µg per 1 kg of body weight for 14 days. A decrease in the content of total triiodothyronine and a significant decrease in the content of free thyroxin are shown. The content of thyroid-stimulating hormones was 2 times higher. Against this background, a lengthening of the duration of hexenal sleep, a decrease in the content of cytochrome P-450 and b5, as well as anilinhydroxylase and amidopyrine-N-demethylase activity of microsomes were revealed. With hyperthyroidism, an increase in free triiodothyronine and thyroxine is shown, against a background of a decrease in the content of total triiodothyronine. The content of thyroid stimulating hormone was reduced. In this case, a decrease in the duration of hexenal sleep, a decrease in the content of cytochrome P-450 against the background of practically no change in the aniline hydroxylase and amidopyrine-N-demethylase activity of microsomes was revealed. It is concluded that the functional and metabolic activity of the liver monooxygenase system is inhibited during hypothyroidism and the activation of the metabolic function of the liver during hyperthyroidism.
Keyword: hypothyroidism, hyperthyroidism, monooxygenase system, thyroid hormones, metabolic function of the liver.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.093
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