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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Optimizing the treatment of biliary disease in children with viral hepatitis

Author: FATIMA MAMATMUSAEVA, LAZIZ TUYCHIEV, ZUKHRA NURUZOVA, NODIRA YODGOROVA, ZUKHRA ORINBAEVA
Abstract: Aim: The aim of the study is to optimize the therapy of biliary pathology in children in case of viral hepatitis A, B and C. Materials and methods: The material of this study was data from 93 children between the ages of 7 and 18 suffering from viral hepatitis A, B and C with biliary disorders. The use of essential phospholipids in biliary system disorders, as well as antiviral action of glycyrrhizic acid have been studied. Results: During the period of reconvalescence with viral hepatitis A, B and C in children, which occurs with biliary system disorders, the combined use of essential phospholipids and glycyrrhizic acid (Phosphogliv preparation) contributed to the rapid restoration of the ratio of the main constituent parameters of bile. The antiviral action of glycyrrhizic acid prevents hepatitis B and C from becoming chronic. Conclusion: In children, during early reconvalescence with viral hepatitis A, B and C, biliary system lesions are accompanied by an increase in blood enzyme 5-nucleotide on average 1.9 times higher than normal, and in biochemical study of bile - a decrease in phosphatidylcholine level. The correlation analysis showed that there was an inverse, strong correlation between blood 5-nucleotide, and phosphotidylcholine values in bile (r = - 0.7). In the group of children with biliary pathology in the combined use of Phosphogliv, normalization of the level of the enzyme 5-nucleotide ase, phosphotidylcholine in bile was noted, as well as elimination of the virus was achieved in 87.5% of cases in viral hepatitis B, in 71.4% of cases in viral hepatitis C.
Keyword: reconvalescents of viral hepatitis, biliary system, Phosphoglive preparation, enzyme 5-nucleotide, bile composition.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.087
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