|
Utility of Microvessel Density and It’s Correlation with Nottingham Prognostic Index in Carcinoma Breast
|
|
| Author:
|
GOYAL ADITI, SHUKLA SAMARTH, VAGHA SUNITA, ACHARYA SOURYA, JAGTAP MIHEER, J. M. KUMBHARE
|
| Abstract:
|
One of the leading causes of malignancy related mortality throughout the world is Carcinoma Breast and Nottingham Prognostic Index (NPI) has shown an excellent correlation with the clinical aggressiveness and prognosis of this disease over the recent years in innumerable studies. The present study is aimed at assessing the utility of Micro Vessel Density (mVD) and developing an understanding of its relationship with Nottingham Prognostic Index (NPI) in Carcinoma Breast. This study includes 80 consecutive cases of primary breast carcinoma over a period of 2 years. Histomorphological features like tumor size, grade, lymph node involvement, necrosis, vascular invasion etc., will be assessed and NPI will be calculated. Immunohistochemical staining for CD34 (to calculate microvessel density [MVD]) in tumour mass, will be performed. Statistical analysis will be used for correlation. Conclusion will be drawn from the results obtained from IHC study, and correlate with the Nottingham Prognostic Index. Micro vessel density is the quantitative factor to determine the angiogenesis and can subordinate the Nottingham Histologic Score system thus, being an adjunct in the grading of Carcinoma Breast.
|
| Keyword:
|
Breast, Carcinoma, Microvessel density, Nottingham prognostic index
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2019.11.04.502
|
| Download:
|
Request For Article
|
|
|