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Role of Ki 67 In Pathological Prognostic Staging of Breast Cancer
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| Author:
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RASHMI WANKHADE, VIVEK GUPTA, AMOLI BELSARE
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| Abstract:
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Breast carcinoma is leading malignancy around the world among women. The judicious use of biomarkers or combinations of biomarkers that plays important role in prognosis. Biomarkers are now believed to be essential in guiding therapy and providing personalized care to the patients. Ki 67 is one of the markers which reflect the proliferative index of tumour cells and it also helps to determine response to chemotherapy. Ki67 can be a good prognostic marker as it reflects high proliferative potential in breast cancer.
Aim: This study aims to establish the correlation between clinicopathological factors, expression of Ki67 with pathological staging in different molecular subtypes of breast cancer for its prognostication.
Methodology: Gross features of resected breast are described and histopathological section stained by H and E stain and immunohistochemical stain are studied.
Results: Ki 67 expression is expected to be more in in highly metastasizing, in tumors of high grade and tumors of relatively large sizes.
Conclusion: The present study will help to establish the correlation between clinicopathological factors and expression of Ki67 in molecular subtypes of breast cancer for its prognostication.
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| Keyword:
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Breast cancer, Ki67, Prognosis, staging.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.164
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| Download:
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