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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Scabies complete clearance as a treatment efficacy: in Permethrin alone and in combined with oral Ivermectin: South Iraq-2019

Author: DR. ABDULHUSSEIN
Abstract: Background: Scabies as an intense itching disease, worldwide occurrence, where poorly sanitation region experience badly natural history of illness, with real problematic impact, had multi management stratigies of different efficacy, response rate and adverse effect. Aim: compare the topical Ivermectin combination with the permethrin 5% efficacy against permethrin 5% cream only as a scabies treatment. Materials and Methods: Interventional comparative study as a randomized controlled trial. Between April 2019 and April 2020, any patients with scabies who were older than 5 years of age and attending the Dermatology outpatient clinic, who visiting the outpatients of dermatology and venereology in Al-Hussein Teaching hospital- Thi-Qar province were assessed for enrolment in the study. Statistical and epidemiological analysis done by SPSS version 25, P value<0.05considersignificant. Results: The study including 373 scabies patients, according to type of treatment they devided into 2 group A: who take combination of oral Ivermectin and topical permethrin (189 patients) with mean age of 27.5 ±11.5years for male, 24.8 ±11.1 while for group B (Permethrin only) the mean age of 28. ±11.7years for male and 24.5 ±10.9years for female, where there was no significant difference between these groups regarding gender distribution according to their age and according to their duration of disease from the time diagnosis measured by days the P value for such difference was of >0.05, mean size of the of the lesion at different occasions of measure, the paired t- test , which proved that at all comparison stage there was significant statistical difference, where P values (0.001), correlation was nearly of medium positive correlations. Lesion categories in crossly matched different types of lesion according to the three different times of measure show very high significant statistical differences. Conclusion: Combined effect of both lines of treatment show significant reduction in the time of treatment and higher complete clearance rate of lesion with full recovery rate without considerable side effect
Keyword: Scabies, Permethrin, Ivermectin, South-Iraq, 2019
DOI: https://doi.org/10.31838/ijpr/2020.12.04.081
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