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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Basaloid Squamous Cell Carcinoma of the Oropharynx - Brief Overview

Author: SRIKUMAR CHAKRAVARTHI, BARANI KARIKALAN
Abstract: Basaloid Squamous cell carcinoma (BSCC) is an unusual and virulent type of squamous cell carcinoma (SCC). BSCC is characterised by the close association of the squamous component with the basaloid component under microscopy. Owing to the rarity of the lesion, clinicopathologic features of these cancers are not sufficiently studied. BSCC has a preference to occur in the upper aerodigestive tract. Tongue followed by hypopharynx and supraglottic larynx are other preferred sites. Males are commonly affected than females with most cases occurring between 60 and 80 years of age. Association with alcohol and tobacco has been demonstrated. BSCC cannot be distinguished from conventional SCC on clinical examination. Definitive diagnosis is based on histopathologic features while immunohistochemical can be used to distinguish from its close differentials including a solid variant of adenoid cystic and neuroendocrine carcinomas. The clinical outcome of BSCC in comparison with conventional SCC is still debatable. BSCC of the oropharynx is found to be associated with human papillomavirus (HPV) positivity more frequently when compared to SCCs of other sites in the head and neck region. In this review, we have discussed the clinical features, histopathological aspects of BSCC and clinical outcome along with a special emphasis on its association to HPV.
Keyword: Squamous cell carcinoma, Basaloid, Oropharynx, human papillomavirus
DOI: https://doi.org/10.31838/ijpr/2020.12.04.053
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