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Evaluation of Anticonvulsant Activity of Ethanolic Extract of Aegle Marmelos Leaves by Various Pharmacological Screening Methods
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UPLOADED BY-ADMIN, MASTAN RAO Y, BHARGAVI CH, APARNA LAKSHMI I, SAROJA M , PRAVEEN KUMAR CH, UMA VENKATESH S
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| Abstract:
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In present study the anticonvulsant activity of ethanolic extract of aegle marmelos leaves by different screening methods.
The anticonvulsant activity of EEAM was estimated by using Maximum electroshock-induced seizure model and pentylene
tetrazole induced seizure model in mice and those showing response were divided into four groups of six animals each.
Group-I (Normal), Group-II (Diazepam 2mg/ Kg , p.o) , Group-III (EEAM 100mg/Kg, p.o), Group-IV(EEAM 200mg/Kg
p.o). The phytochemical studies revealed alkaloids, Flavonoids, Saponins, carbohydrates as their chemical
constituents. Animals which were treated with EEAM with 100mg/Kg and 200mg/Kg p.o were shown significant
action (45%, 65% respectively) with the doses when compared with the standard Diazepam(2mg/Kg) which has 100%
inhibitory action. The comparative study was done by ONE WAY ANOVA followed by Dunnet`s test. Since the Ethanolic
extract of Aegle marmelos delayed the occurrence of MES and PTZ convulsions, it is probable that it may be
interfering with Gabaergic mechanism(s) to exert their anticonvulsant effect.
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Aegle marmelos , anticonvulsant, Diazepam, PTZ .
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