IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Evaluation of Anticonvulsant Activity of Ethanolic Extract of Aegle Marmelos Leaves by Various Pharmacological Screening Methods

Author: UPLOADED BY-ADMIN, MASTAN RAO Y, BHARGAVI CH, APARNA LAKSHMI I, SAROJA M , PRAVEEN KUMAR CH, UMA VENKATESH S
Abstract: In present study the anticonvulsant activity of ethanolic extract of aegle marmelos leaves by different screening methods. The anticonvulsant activity of EEAM was estimated by using Maximum electroshock-induced seizure model and pentylene tetrazole induced seizure model in mice and those showing response were divided into four groups of six animals each. Group-I (Normal), Group-II (Diazepam 2mg/ Kg , p.o) , Group-III (EEAM 100mg/Kg, p.o), Group-IV(EEAM 200mg/Kg p.o). The phytochemical studies revealed alkaloids, Flavonoids, Saponins, carbohydrates as their chemical constituents. Animals which were treated with EEAM with 100mg/Kg and 200mg/Kg p.o were shown significant action (45%, 65% respectively) with the doses when compared with the standard Diazepam(2mg/Kg) which has 100% inhibitory action. The comparative study was done by ONE WAY ANOVA followed by Dunnet`s test. Since the Ethanolic extract of Aegle marmelos delayed the occurrence of MES and PTZ convulsions, it is probable that it may be interfering with Gabaergic mechanism(s) to exert their anticonvulsant effect.
Keyword: Aegle marmelos , anticonvulsant, Diazepam, PTZ .
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free