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Discriminant indices for distinguishing beta thalassemia trait from iron deficiency anaemia: work up at microcytic hypochromic anaemia
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| Author:
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ANKITA SAIN, ANIL AGRAWAL, ARVIND BHAKE, SUNITA VAGHA, J. M. KUMBHARE
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| Abstract:
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Background: Hematological indices to discriminate beta thalassemia trait (ßTT) and iron deficiency anemia (IDA) in morphological situation of microcytic anemia have been proposed to be helpful. There are 40 mathematical indices in hematology literature to bring about discrimination between above two anemia microcytic hypochromic (MCHC) anemia picture on peripheral smear. The literature revealed the Mentzer, Green and King, Srivastava and Sirdah indices as the most popular and practiced indices to discriminate MCHC anemia due to thalassemia and IDA.
Objectives: (1) To draw and compare the values of these indices in the MCHC anemia in laboratory confirmed groups of Thalassemia and IDA. (2) To calculate the power of the discriminant indices for sensitivity (SN), specificity (SP), Positive Predictive Value (PPV) and Negative Predictive Value (NPV), to compare their performances.
Methodology: Study Design: a Prospective Study; Sample Size & Sample Character: 50 patients each in two groups with laboratory diagnosis of beta Thalassemia and IDA; Methods: 7 part electronic cell counter to derive the values; Formulae: standard formulae for Mentzer, Green & King, Srivastava and Sirdah indices; Statistical Methods : SN, SP, PPV and NPV for both the groups.
Results: This study expects Mentzer index as well as Green and King index to perform better at distinguishing ßTT and IDA as compared to rest of all indices evaluated.
Conclusion: The ßTT can be distinguished from IDA on the results of studied indices by high levels of confidence and therefore, are suitable to be applied in resource poor laboratories where facilities for Hb electrophoresis and iron studies are not available.
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| Keyword:
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Discriminant indices, iron deficiency, microcytic hypochromic anemia, beta thalassemia trait.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.206
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| Download:
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