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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The immunoexpression profile of cyclin d1, Ki67 and P53 in evaluation of endometrial hyperplasia state and endometrial carcinoma

Author: DR. SHWETA, DR. BHAKE ARVIND, DR. VAGHA SUNITA, DR.KAVITA SINGH
Abstract: Background:There exists the histomorphological mimics at practice of endometrial pathology wherein difficulties are encountered at distinguishing endometrial hyperplastic lesion from low grade endometrial carcinoma. The WHO proposed category of complex hyperplasia with atypia still challenges histomorphological differentiation of it from Type 1 endometrial carcinoma ( well differentiated ). Maximal false negative or false positive diagnosis are entertained in this category. Cyclin D1 , Ki-67 and p53 in the few studies have also been correlated at differentiating low grade endometrial carcinoma from complex endometrial hyperplasia with atypia , the type of endometrial carcinoma and for the purpose of prognosis(1-13) and treatment options. Objectives-To compare the expression of cyclin D1, Ki-67 and p53 in proliferative lesions of endometrial hyperplasia (WHO categories) and endometrial carcinoma (Type 1, low grade) with control group of endometrium in proliferative phase, to study cyclinD1, Ki-67 AND p53 for inter variable comparisons endometrial hyperplasia (with atypia), endometrial hyperplasia without atypia and endometrial carcinoma) and to evaluate cyclinD1, Ki-67 and p53 at distinction between the complex hyperplasia with atypia from that of endometrial carcinoma ( Type 1, low grade ). Study design and methodology: A study will be carried out with dual arms of retrospective [7years] and prospective [2 years] observation in Department of Pathology, JNMC, Sawangi (Meghe), DMIMS , WARDHA over a period of 2 years [2019-2021]. A total of 100 samples of the endometrium of 100 patients divided in four groups of mid proliferative phase, simple and complex endometrial hyperplasia without atypia ,simple and complex endometrial hyperplasia with atypia and endometrial carcinoma with 25 cases in each group. Paired comparison and intervariable statistical methods will be applied to draw the conclusions for significance. The preliminary data of name, age, MRD,OPD, IPD unit of care and its head and occupation and address will be recorded. The recording of symptoms and signs pertaining to endometrial pathology will also be recorded with provisional diagnosis. Additionally USG will also be noted for its significant findings. Result and conclusion-Immunohistochemistry of CYCLIN D1, Ki67 and TP53 could help dissolving the histomorphological dilemma specially in complex hyperplasia with atypia from endometrial carcinoma. Study is limited by non-inclusion of other auxiliary immunohistochemically detected parameters such as PTEN. Immunohistochemistry for CYCLIN D1 , Ki-67 and TP53 included as routine protocol immunohistochemistry in histomorphology overlaps at the different endometrial hyperplasia with atypia from endometrial carcinoma.
Keyword: Cyclin D1, Ki-67, p53, Endometrial Hyperplasia, Endometrial Carcinoma
DOI: https://doi.org/10.31838/ijpr/2019.11.01.213
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