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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Haematological profile in patient of sickle cell anaemia in Vidarbha region

Author: POOJA CHANDAK, DR. ANJALI VAGGA, GAURI AJAY CHAUDHARY
Abstract: Background: Sickle cell anaemia is an autosomal recessive disease wherein amino acid at the 6th position of the chain is replaced by some other amino acid. In this disease, the shape of erythrocytes is changed from oval to sickle cell. First time the sickle cell anaemia was considered as a haematological disorder more than 100 years ago and as a molecular disorder in 1949. Objectives 1) To know the status of blood gas profile in homozygous and heterozygous patients of sickle cell anaemia. 2) To know the count of RBCs, WBCs and platelets in homozygous and heterozygous patients of sickle cell anaemia. 3) To know the concentration of haemoglobin in patients of homozygous and heterozygous sickle cell anaemia. 4) To know the electrophoretic pattern in patients of homozygous and heterozygous sickle cell anaemia. Methodology: It will be a diagnostic type of study wherein 4 parameters will be assessed. they are blood gas levels, complete blood count, haemoglobin levels and electrophoretic patterns. Sample size of 60 patients will be taken which would then be divided into 2 groups. Their reports would be studied upon thereafter. During analysis tests like Chi square test and student’s unpair test will be performed along with excel sheets, bar graphs, etc. Results: The expected results are occurrence of low levels of Haemoglobin, Complete blood count and blood gas. Also, abnormal electrophoretic patterns are expected.
Keyword: Sickle cell anaemia, Haematological profile, Vidarbha Region.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.205
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