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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and evaluation of diacerein microemulgel topical drug delivery.

Author: GANESH PAWBAKE, SATISH V. SHIROLKAR
Abstract: The research concept for Diacerein production that includes Microemulgel formulation that can be used for the delivery of topical drugs. For Diacerein, microemulgel formulations were designed to improve the effect, regulated permeation, increase drug solubilization ability and reduce oral drug delivery drawbacks. Capmul MCM C8, Labrasol, and Ethanol respectively selected as oil , surfactant, and cosurfactant. Twenty seven formulations were prepared using the central composite design, with varying ranges of S mix and oil phage. During in-vitro trials, the prepared batch F2 represents a 95% higher release in 8h. Drug diacerein and excipients reflect little contact at all. Based on this analysis, prepared batch F2 selected for final batch of formulation because it shows good thermodynamic stability, percentage transmittance, shows good drug quality and higher cloud level, in case of higher drug release check in vitro diffusion.
Keyword: Microemulgel, topical drug delivery, Diacerein, microemulsion.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.066
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