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Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design, Development and Evaluation of Atazanavir Sulphate Agglomerates by Crystallo Co-Agglomeration Technique

Abstract: Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to produce the drugs with good micromeritic and mechanical characteristics. Atazanavir sulphate is an anti-retroviral drug with poor dissolution and poor flow properties. Hence the aim of the study is to prepare the crystallo co-agglomerates of atazanavir sulphate which may improve the properties of atazanavir sulphate. The present study was carried out in order to develop pharmaceutically equivalent, stable, and quality improved agglomerates of atazanavir sulphate with enhanced solubility wettability, dissolution rate, flow properties and mechanical properties using hydrophilic polymers and to characterize the physico-chemical properties of prepared crystallo-co-agglomeration. The present work was carried out using PVA and PEG 6000 as the polymers in different ratios by crystallo-co agglomeration method. The various evaluations of prepared agglomerates like micromeritics of the agglomerates such as flowability, packability and compatibility were dramatically improved. The dissolution and disintegration rate of agglomerate was increased in presence of PEG 6000 than compared with PVA. The atazanavir sulphate polymer agglomerates were successfully prepared by crystallo-co-agglomeration technique and it was concluded that crystallo-co-agglomeration technique can be successfully employed as an alternative to conventional wet agglomeration.
Keyword: Crystallo-co-agglomeration, Atazanavir sulphate, Anti-Retroviral, X-Ray Diffraction, Scanning Electron Microscopy, Head Space Gas Chromatography.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.063
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