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An Overview on Floating Microsphere
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| Author:
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RAGHAV MISHRA, ACHYUT MISHRA
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| Abstract:
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In the course of the years, the research and development of new drug delivery systems have enabled scientific and technological advancements by overwhelming physiological tasks such as the short gastric residence duration. There are currently a number of methodologies employed to delay gastric residence. In order to achieve long gastric residence, floating drug delivery systems, are introduced. Floating microsphere, a floating drug delivery system is based on non-effervescent approach. These are spherical, no-core void particles with low density that can remain in the stomach for a delayed period of time. The medication releases from it at a requested rate which results in increased absorption and decreased variances in plasma drug levels and thus improved therapeutic results of short half-life drugs can be achieved. Recent advances have demonstrated that floating microspheres are especially suitable for mixing sustained or delayed releases in order to achieve different release models with low dumping risk. The present status of floating microsphere including, advantages and disadvantages, preparation process, characterization, in vitro studies and commercial utilities are discussed in this review.
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| Keyword:
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Floating microsphere, Floating drug delivery system, Gastric Residence Time, Characterization, Patents.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.058
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| Download:
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Request For Article
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