IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Investigation phytochemical screening, antibacterial activity, and cytotoxic ethanolic extract of Geodorum densiflorum (lam.) Schltr from papua

Author: ELSYE GUNAWAN, VERENA AGUSTINI, EVA SUSANTY SIMAREMARE
Abstract: One of ten species of orchid plant (genus Geodorum) that widespread in tropical forests of Asia including Indonesia (Papua) is Geodorum densiflorum. G. densiflorum showed significant pharmacological activities such as antibacterials, cytotoxic, antioxidant, antifungal, thrombolytic, and analgesic. So this study aims were to determine the active compounds, antibacterial activity, and cytotoxicity extracts and fractions of G. densiflorum coming from Papua. Samples (leaves and tubers) of G. densiflorum were made in simplicia, extracted with ethanol and fractionated using n-hexane, ethyl acetate, and ethanol solvent. Extract as well as fraction were tested for phytochemical screening then determined antibacterial activity against Staphylococcus aureus bacteria by Disc Diffusion Method. In spite of cytotoxic test was used Brine Shrimp Lethality Test (BSLT) method with variation of extract and fraction 10, 50, 100, 250, 500, 750, and 1000 ppm. The results showed that the extract G. densiflorum positive contained tannin and alkaloids in leaves futhermore flavanoids and alkaloid in tubers. G. densiforum has activity inhibiting the growth of S. aureus bacteria. The zone of inhibition extract were in [8 mm (leaves), 8 mm (tuber)] and maximum fraction were in [n-hexane solvent was 8 mm (leaf) and ethanol was 7 mm (tuber)]. The cytotoxic test showed that LC50 extract were in [1281.4 ppm (leaf) and 1640.9 ppm (tuber)] during the maximum LC50 the fraction of n-hexane were in [739.2 ppm (leaf) and 785 ppm (tuber)]
Keyword: G. densiflorum, phytochemical screening, antibacterial, cytotoxicity, Papua
DOI: https://doi.org/10.31838/ijpr/2020.12.04.048
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free