IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
New safety signal for psoriasis associated with Angiotensin receptor blockers: qualitative and quantitative analysis using Pharmacovigilance tools

Author: HARDIK BHATT, TUSHAR DESAI
Abstract: Study objective: To qualitatively and quantitatively analyze the association between use of Angiotensin receptor blocker class of drugs and psoriasis from Canadian Adverse Reaction database and published literature. Research Design and method: Reports of psoriasis associated with use of Angiotensin receptor blocker class of drug were retrieved from public version of Canadian Adverse Reaction (CADRMP) database between January 2000 and December 2016 and analyzed for quantitative signal detection by data mining algorithms mainly reporting odds ratio (ROR), proportional reporting ratios (PRR) and 95% confidence interval (CI) of PRR. Also for qualitative analysis, reports for psoriasis associated with ARBs were obtained from literature regulatory agency reports for period from 2000 to 2016. Results: Based on CADRMP data from January 2000 and December 2016, total 9 reports were obtained for psoriasis associated with use of ARBs. Thus, as per our results obtained; value of PRR, ROR and 95% CI for PRR were found to be 17.5, 17.7 and 4.4, respectively indicating significant new signal for aggravated psoriasis associated with ARBs use, however these signals were stronger for Valsartan than other ARBs. Conclusions: Thus public version of CADRMP database as well as literatures and regulatory agency report represents an important source to detect signals of psoriasis. In particular, our present study generated significant new signals for psoriasis among ARBs for which further investigations and active surveillance are warranted. These signals should be considered in evaluating the benefit-risk profile of these drugs.
Keyword: Angiotensin receptor blocker, Signal detection, Adverse drug events, Psoriasis
DOI: https://doi.org/10.31838/ijpr/2020.12.04.068
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free