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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Hepatoprotective Potential of Solanum melongena L. Fruit Peel Extract against Carbon Tetrachloride Induced Liver Damage in Wistar Rats

Author: JAIDEEP SARKAR, NITIN KUMAR, PANKAJ GUPTA
Abstract: Context: Solanum melongena fruits have been recommended in liver complaints and has been a remarkable source causing reduction in free radicals in body. Aim: This study was planned to evaluate in-vivo anti-oxidant and subsequent hepatoprotective activity of hydro-alcoholic (SMHA) and aqueous extract (SMAQ) of purple colour fruit peels of Solanum melongena L. Methods and Materials: SMHA and SMAQ extracts of S. melongena L. purple were tested for acute oral toxicity study in Swiss albino mice at 75, 150, 250, 500, 1000, and 2000 mg/kg/bw. No mortality or evident signs of toxicity was reported. Based on the results, 100, 200, and 400 mg/kg were selected and orally administered to Carbon Tetrachloride (CCl4 mixed in olive oil and injected s.c.) induced hepatotoxic Wistar rats. Serum (fasting sugar, AST, ALT, ALP, TC, TG, and HDL) and tissue bio-chemical estimation (SOD and GSH level) were performed in addition to microscopical examination on hepatocytes. Results: Serum and liver biomarker enzymes in rats have attenuated in dose dependent manner and were reported to be within normal ranges post treatment with SMHA and SMAQ. There was observed reduced fatty deposits or adipocytes infiltration in hepatocytes with rapid healing effects. Statically, all the reported findings for serum and tissue pathology were with p<0.05. Conclusion: Peels of S. melongena L. possess excellent anti-oxidant potential and thereby subsequent hepato-protective activity too by attenuating free radicals and elevated liver biomarker enzymes. S. melongena L can be used as a great functional food for liver compromised people.
Keyword: carbon tetrachloride, free radical scavenging, functional food, hepatoprotective, lipid peroxidation, Nasunin.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.024
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