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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Novel technique used in the design of floating tablets of captopril and its evaluation

Author: MUNAGALA RAMYA, KOTHAPALLI BANNOTH CHANDRASEKHAR
Abstract: The goal of the present work was to develop a gastro-retentive floating captopril tablet and to investigate the Impact of polymer, thermal sintering at various temperature and exposure period on in vitro release. Captopril is an antihypertensive drug with an oral bioavailability of 70 percent due to poor absorption from lower GIT. The floating tablets were prepared to increase gastric residence time, to prolong the drug release and to enhance the bioavailability of the drug. The floating tablets were formulated using PEO polymer and sodium bicarbonateas a gas generating agent to decrease the floating lag time. Formulated tablets were thermally treated and evaluated for the quality control tests such as weight variation, hardness, friability, floating lag time and total floating time. In vitro drug release study of unsintered and sintered tablets were performed in 0.1N HCl as dissolution media. Results of the present study clearly evident that promising of captopril floating system as an alternative to the conventional dosage and other sustained release formulations. The study also revealed the effectiveness of Thermal sintering and time of exposure.
Keyword: Sintering, calcium carbonate, time of exposure, in vitro drug release
DOI: https://doi.org/10.31838/ijpr/2020.12.04.020
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